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SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.1
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
Vitamin D may influence blood clotting
Relationship between vitamin D deficiency and thrombus load in patients with ST-elevation myocardial infarction.
Study highlights vitamin D's impact
We explored the connection between vitamin D levels and coronary thrombus load in patients who experienced ST-elevation myocardial infarction (STEMI). The study included 77 patients where we measured serum vitamin D levels, thrombus degree, and other relevant factors.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
Read More
4
Vitamin D3 had limited effects
The Effect of High-Dose Vitamin D3 on Soluble P-Selectin and hs-CRP Level in Patients With Venous Thromboembolism: A Randomized Clinical Trial.
Direct investigation on blood clotting
We investigated the effects of high-dose vitamin D3 on blood clotting parameters in patients suffering from venous thromboembolism (VTE), specifically looking at levels of P-selectin and high-sensitive C-reactive protein (hs-CRP). The study involved 60 participants who were diagnosed with acute deep vein thrombosis or pulmonary embolism.
These patients were randomly divided into two groups—one receiving a single dose of 300,000 IU of vitamin D3 and the other group serving as a control. Over the course of four weeks, we measured the levels of vitamin D, P-selectin, and hs-CRP to assess any changes resulting from the treatment.
While we noticed a significant decline in both P-selectin and hs-CRP in those who received vitamin D3, the overall reductions were not substantial enough to indicate a major benefit. In comparison, only hs-CRP decreased significantly in the control group. Therefore, we conclude that, based on our findings, high-dose vitamin D3 does not show a strong impact on lowering P-selectin levels or hs-CRP in patients with VTE.
These patients were randomly divided into two groups—one receiving a single dose of 300,000 IU of vitamin D3 and the other group serving as a control. Over the course of four weeks, we measured the levels of vitamin D, P-selectin, and hs-CRP to assess any changes resulting from the treatment.
While we noticed a significant decline in both P-selectin and hs-CRP in those who received vitamin D3, the overall reductions were not substantial enough to indicate a major benefit. In comparison, only hs-CRP decreased significantly in the control group. Therefore, we conclude that, based on our findings, high-dose vitamin D3 does not show a strong impact on lowering P-selectin levels or hs-CRP in patients with VTE.
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9
Vitamin D3 impacts blood clotting
1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.
Significant effects seen in study
We explored the effects of vitamin D3 on blood clot formation in mice lacking the klotho protein, which plays a role in regulating vitamin D3 levels. In our analysis, we focused on how klotho deficiency impacts platelet function and calcium signaling, pivotal mechanisms involved in clotting.
Our findings revealed that klotho-deficient platelets exhibited significantly reduced responses to activation, indicating that they might not form clots effectively. Specifically, we observed that calcium signaling pathways, essential for platelet activation and aggregation, were notably inhibited in these mice. The investigation utilized multiple methods, including measuring calcium levels and evaluating platelet function through various biochemical and cellular techniques.
Interestingly, when klotho-deficient mice were given a low-vitamin D diet, we discovered that their platelet function improved, suggesting a direct link between vitamin D3 levels and platelet activity. The reduced activity was associated with decreased expression of critical signaling proteins involved in calcium entry, which vitamin D3 helps regulate. Overall, our study presents evidence that vitamin D3 deficiency due to klotho absence may hinder proper blood clotting mechanisms.
Our findings revealed that klotho-deficient platelets exhibited significantly reduced responses to activation, indicating that they might not form clots effectively. Specifically, we observed that calcium signaling pathways, essential for platelet activation and aggregation, were notably inhibited in these mice. The investigation utilized multiple methods, including measuring calcium levels and evaluating platelet function through various biochemical and cellular techniques.
Interestingly, when klotho-deficient mice were given a low-vitamin D diet, we discovered that their platelet function improved, suggesting a direct link between vitamin D3 levels and platelet activity. The reduced activity was associated with decreased expression of critical signaling proteins involved in calcium entry, which vitamin D3 helps regulate. Overall, our study presents evidence that vitamin D3 deficiency due to klotho absence may hinder proper blood clotting mechanisms.
Read More
Most Useful Reviews
9.5
Cramps disappeared
My vitamin D level was only 11 ng/ml, but after just a month of taking this supplement, it rose to 35 ng/ml and my leg cramps vanished. I highly recommend it.
Read More
9.5
Restored levels
I had a deficiency in vitamin D, with my levels at 17 ng/ml. After three months of taking this supplement, I tested again, and they rose to a normal 50 ng/ml. My family and I take one tablet every other day, along with half a teaspoon of olive oil for better absorption.
Read More
1.3
Persistent deficiency
I took this vitamin regularly for two months, but my blood test still showed a deficiency in vitamin D.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.1
9
Vitamin D3 impacts blood clotting
1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.
Significant effects seen in study
We explored the effects of vitamin D3 on blood clot formation in mice lacking the klotho protein, which plays a role in regulating vitamin D3 levels. In our analysis, we focused on how klotho deficiency impacts platelet function and calcium signaling, pivotal mechanisms involved in clotting.
Our findings revealed that klotho-deficient platelets exhibited significantly reduced responses to activation, indicating that they might not form clots effectively. Specifically, we observed that calcium signaling pathways, essential for platelet activation and aggregation, were notably inhibited in these mice. The investigation utilized multiple methods, including measuring calcium levels and evaluating platelet function through various biochemical and cellular techniques.
Interestingly, when klotho-deficient mice were given a low-vitamin D diet, we discovered that their platelet function improved, suggesting a direct link between vitamin D3 levels and platelet activity. The reduced activity was associated with decreased expression of critical signaling proteins involved in calcium entry, which vitamin D3 helps regulate. Overall, our study presents evidence that vitamin D3 deficiency due to klotho absence may hinder proper blood clotting mechanisms.
Our findings revealed that klotho-deficient platelets exhibited significantly reduced responses to activation, indicating that they might not form clots effectively. Specifically, we observed that calcium signaling pathways, essential for platelet activation and aggregation, were notably inhibited in these mice. The investigation utilized multiple methods, including measuring calcium levels and evaluating platelet function through various biochemical and cellular techniques.
Interestingly, when klotho-deficient mice were given a low-vitamin D diet, we discovered that their platelet function improved, suggesting a direct link between vitamin D3 levels and platelet activity. The reduced activity was associated with decreased expression of critical signaling proteins involved in calcium entry, which vitamin D3 helps regulate. Overall, our study presents evidence that vitamin D3 deficiency due to klotho absence may hinder proper blood clotting mechanisms.
Read More
9
Vitamin D3 reduces blood clot risk
Renin angiotensin system blockade and activated vitamin D as a means of preventing deep vein thrombosis in renal transplant recipients.
Moderate relevance to vitamin D3
We evaluated the potential of vitamin D3, specifically calcitriol, in combination with other medications to prevent deep vein thrombosis (VTE) in renal transplant recipients (RTR). Focusing on how these treatments might influence the occurrence of blood clots, we followed a group of 769 RTRs over several months post-transplant.
Our findings revealed that 96 of these recipients experienced a first episode of VTE. We noticed a significant difference in rates of blood clots among those who received calcitriol alongside angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs). In fact, recipients on the combination therapy had a markedly lower rate of VTE, showing a promising 60% reduction in risk.
However, it is important to note that the isolated effect of vitamin D3 without other treatments wasn't fully determined in this study. While calcitriol showed favorable outcomes when used with blood pressure medications, further research could help clarify its individual impact on clot prevention. Overall, this research highlights the importance of collaborative strategies in managing thrombotic complications for transplant patients.
Our findings revealed that 96 of these recipients experienced a first episode of VTE. We noticed a significant difference in rates of blood clots among those who received calcitriol alongside angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs). In fact, recipients on the combination therapy had a markedly lower rate of VTE, showing a promising 60% reduction in risk.
However, it is important to note that the isolated effect of vitamin D3 without other treatments wasn't fully determined in this study. While calcitriol showed favorable outcomes when used with blood pressure medications, further research could help clarify its individual impact on clot prevention. Overall, this research highlights the importance of collaborative strategies in managing thrombotic complications for transplant patients.
Read More
8
Vitamin D3 reduces platelet aggregation
1,25-Dihydroxyvitamin D3 attenuates platelet aggregation potentiated by SARS-CoV-2 spike protein via inhibiting integrin αIIbβ3 outside-in signaling.
Study shows limited isolated effect
We focused on how 1,25-Dihydroxyvitamin D3, or vitamin D3, affects platelet aggregation, particularly in response to the SARS-CoV-2 spike protein. Individuals with COVID-19 often experience heightened blood clotting, which can lead to serious complications. Our study aimed to uncover the mechanisms behind vitamin D3’s potential benefits in reducing this risk.
Through our experiments, we discovered that vitamin D3 helped reduce platelet aggregation triggered by the spike protein. We noticed that it inhibited certain signaling pathways inside platelets, thereby curbing their ability to clump together. Even when the spike protein was introduced, vitamin D3 managed to lessen the platelet response significantly.
Interestingly, our findings suggest that vitamin D3 works by modulating a specific integrin signaling pathway, known as integrin αIIbβ3 outside-in signaling. We observed that this process involved key proteins that play a role in platelet function. Combining vitamin D3 with a Src family kinase inhibitor showed no added benefits, indicating that vitamin D3's effects might be closely tied to these signaling pathways.
Overall, our study indicates that vitamin D3 has a beneficial role in mitigating the heightened platelet activity associated with the spike protein, offering insights into its potential use as a treatment option during COVID-19.
Through our experiments, we discovered that vitamin D3 helped reduce platelet aggregation triggered by the spike protein. We noticed that it inhibited certain signaling pathways inside platelets, thereby curbing their ability to clump together. Even when the spike protein was introduced, vitamin D3 managed to lessen the platelet response significantly.
Interestingly, our findings suggest that vitamin D3 works by modulating a specific integrin signaling pathway, known as integrin αIIbβ3 outside-in signaling. We observed that this process involved key proteins that play a role in platelet function. Combining vitamin D3 with a Src family kinase inhibitor showed no added benefits, indicating that vitamin D3's effects might be closely tied to these signaling pathways.
Overall, our study indicates that vitamin D3 has a beneficial role in mitigating the heightened platelet activity associated with the spike protein, offering insights into its potential use as a treatment option during COVID-19.
Read More
8
Vitamin D may influence blood clotting
Relationship between vitamin D deficiency and thrombus load in patients with ST-elevation myocardial infarction.
Study highlights vitamin D's impact
We explored the connection between vitamin D levels and coronary thrombus load in patients who experienced ST-elevation myocardial infarction (STEMI). The study included 77 patients where we measured serum vitamin D levels, thrombus degree, and other relevant factors.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
Read More
8
Vitamin D3 may influence thrombosis
Are vitamin D receptor activators useful for the treatment of thrombosis?
Moderate relevance due to context.
We explored how vitamin D3, particularly its active form known as calcitriol, influences blood clotting. This investigation was driven by increasing evidence suggesting that vitamin D receptor (VDR) activators, like calcitriol, could play a role in managing thrombosis, a condition where blood clots form excessively.
The study we reviewed highlighted how VDRs might adjust the activity of various factors that influence thrombogenicity, which is the tendency to form clots. Specifically, a clinical trial indicated that calcitriol might help reduce thrombotic events related to cancer. It was noted that mice lacking VDR showed higher thrombogenic activity, indicating that VDR plays a significant role in blood clot regulation.
Overall, we found promising insights regarding the potential usefulness of VDR activators like vitamin D3 in thrombosis treatment. However, while the findings are encouraging, it's important to recognize that these results are tied to specific contexts, such as oncology-related scenarios.
The study we reviewed highlighted how VDRs might adjust the activity of various factors that influence thrombogenicity, which is the tendency to form clots. Specifically, a clinical trial indicated that calcitriol might help reduce thrombotic events related to cancer. It was noted that mice lacking VDR showed higher thrombogenic activity, indicating that VDR plays a significant role in blood clot regulation.
Overall, we found promising insights regarding the potential usefulness of VDR activators like vitamin D3 in thrombosis treatment. However, while the findings are encouraging, it's important to recognize that these results are tied to specific contexts, such as oncology-related scenarios.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.8
9.5
Cramps disappeared
My vitamin D level was only 11 ng/ml, but after just a month of taking this supplement, it rose to 35 ng/ml and my leg cramps vanished. I highly recommend it.
9.5
Restored levels
I had a deficiency in vitamin D, with my levels at 17 ng/ml. After three months of taking this supplement, I tested again, and they rose to a normal 50 ng/ml. My family and I take one tablet every other day, along with half a teaspoon of olive oil for better absorption.
8.8
Improved immunity
This is not the first time I have taken vitamin D. My levels were at 27 ng/ml before taking it. Following the doctor's advice, I took 5000 units daily and later increased it to 5000 units every other day. After over a year, my levels rose to 84 ng/ml. Vitamin D is crucial for calcium absorption, especially since I have had my thyroid gland removed. It helps regulate the immune system, protecting me from various microorganisms.
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3.5
Chest pain links
I began giving vitamin D to my mother, who is obese and not very active, but she noticed chest pain at night. This pain correlated with the vitamin D and calcium relationship, possibly leading to blood clots. Administering lemon juice subsided her chest tightness. It's crucial to consider an individual's lifestyle and physique before starting this vitamin.
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1.3
Persistent deficiency
I took this vitamin regularly for two months, but my blood test still showed a deficiency in vitamin D.
